![]() Tendon tissues are predominantly composed of collagen and non-collagenous extracellular matrix (ECM) components including proteoglycans, the turnover of which is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Different training types did not appear to induce differential tendon responses in terms of protein synthesis, and while tendons from older adults exhibited different transcriptional responses to younger individuals, protein turnover changes with training were similar for both age groups.Īgeing is associated with progressive structural and mechanical changes to collagen-rich tissues such as tendon, and in elderly individuals, this can have negative impacts on tissue function and contribute to functional disabilities and injuries. At the transcriptional level however, ECC in young adults generally induced greater responses of collagen and extracellular matrix-related genes than CON, while older individuals had reduced gene expression responses to training. ![]() There were increases in tendon protein synthesis following 4 weeks of CON and ECC training ( P < 0.01 main effect by ANOVA), with no differences observed between young and old males, or training type. ![]() Subjects consumed D 2O throughout the protocol and tendon biopsies were collected after 4 and 8 weeks for measurement of fractional synthetic rates (FSR) of tendon protein synthesis and gene expression. Healthy younger males (age 23.5 ± 6.1 years n = 27) and older males (age 68.5 ± 1.9 years n = 27) undertook 8 weeks of CON or ECC training (3 times per week at 60% of 1 repetition maximum (1RM)) or no training. ![]() The aims of the present study were to determine the molecular changes with ageing in patellar tendons in humans, as well as the responses to exercise and exercise type (eccentric (ECC) and concentric (CON)) in young and old patellar tendon. Exercise training can induce adaptive changes to tendon tissue both structurally and mechanically however, the underlying compositional changes that contribute to these alterations remain uncertain in humans, particularly in the context of the ageing tendon. ![]()
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